Manchester City have already knocked Chelsea out of the League Cup and the defending Premier League champions claimed victory at Stamford Bridge in midweek.
Sitting 10 points off fourth, the Blues will hope the FA Cup can provide some respite from a difficult league season.
Graham Potter’s injury crisis worsened on Thursday with Christian Pulisic and Raheem Sterling both leaving the game in the first half.
They join Wesley Fofana, Reece James, Ben Chilwell, N’Golo Kante and Armando Broja on the sidelines. Ruben Dias and Aymeric Laporte are City’s only absentees.
To Win To Nil: Manchester City
Chelsea gave City a good game on Thursday, but ultimately lacked the cutting edge to take advantage of their play.
In contrast, all it took was a moment or two of quality from City to slice open a Chelsea back line which has been found wide open far too often of late.
The rotation factor is real here, with Guardiola potentially resting some of his key players due to such a short break between fixtures.
City have the far superior squad depth, though, and should be able to record another win to nil over Chelsea.
To Record An Assist: Jack Grealish
City enjoyed success when they stretched the pitch against Chelsea on Thursday with the width of Jack Grealish and Riyad Mahrez causing the Blues issues.
Grealish should start on Sunday as a result, and he has a very favourable matchup against veteran right-back Cesar Azpilicueta.
Not only did Grealish create the winner on Thursday, but he is also second on the expected assist per 90 chart.
Gradually finding his role under Pep Guardiola, the England international is a good bet to create another goal this weekend.
To Be Shown A Card: Conor Gallagher
Booked twice in 193 Champions League minutes and already with a Premier League red card to his name this season, Conor Gallagher is no stranger to the referee’s notebook.
The former Crystal Palace loanee could be rotated into the XI after a second-half cameo in the week.
Energetic and occasionally reckless, he’s a significant yellow card risk for Chelsea against City’s intricate midfield play.
All odds are subject to change