Uruguay were held to a draw by South Korea after registering a lone shot on target.
They are not at risk of elimination on Monday, but defeat would leave them in a very difficult position going into the final round of fixtures.
After a turgid first half, Portugal and Ghana played an enthralling second 45, with Os Navegadores ultimately taking all three points.
Total Goals: Under 2.5
There has been under 2.5 goals in six of Uruguay’s last eight matches.
Their attack was lacking creativity in the draw with South Korea, and Diego Alonso faces a difficult decision with Luis Suarez following a poor showing from the former Liverpool striker.
Portugal scored three in their opening match, but needed a very soft penalty call in their favour. When Ghana sat deep, Fernando Santos’ team were ineffective in attack. It is baffling that Santos did not start Rafael Leao.
Total Cards: Over 4.5
These teams are well-matched, and both know the stakes are very high here. This is a fixture where tempers could erupt and many of the sport’s dark arts will be on display.
Each team made more tackles than their opponents in the opening match. This could be an intense match, which might be difficult to officiate.
Cards seem inevitable for both teams — a red card to be shown is also decent value at 22/5.
Anytime Goalscorer: Edinson Cavani
Edinson Cavani scored both goals as Uruguay got the better of Portugal in the World Cup four years ago (their first meeting since 1972).
The veteran striker had to come off the bench in the opener, but Alonso should reconsider Cavani’s role.
Uruguay were more dangerous once Cavani came off the bench.
While he is a long way from the player we saw at the World Cup four years ago, the Salto native is still a reliable goalscorer with four in 430 La Liga minutes for Valencia and five in eight caps this calendar year.
All odds are subject to change