That leaves an opening at SW19 this year, one which is likely to be filled by rising superstar Iga Swiatek.
Winner: Iga Swiatek 6/4
Swiatek is rightly the favourite to win Wimbledon, after establishing herself as the dominant player in women’s tennis since Barty’s retirement.
Swiatek comes into the event having won 35 successive matches, a remarkable record that culminated with the 21-year-old Pole winning her first grand slam at the French Open.
The world No. 1 has claimed five other titles during that time, although she has not played competitively since Roland Garros due to a shoulder injury.
That is likely to be the biggest obstacle to her extending her incredible run of form even further.
Winner: Coco Gauff 14/1
Coco Gauff is well-placed to challenge Swiatek.
Gauff reached her first slam final at this year’s French Open, where she lost in straight sets, and she has history at Wimbledon.
The American introduced herself to the world when she reached the fourth round of this event aged 15 in 2019, beating Venus Williams along the way.
Now 18, Gauff reached the same stage last year but is poised to progress even further this time.
Winner: Serena Williams 22/1
Serena Williams’ odds reflect past achievements, rather than any future ones.
Williams has not played competitively since losing in the first round of Wimbledon 12 months ago.
The 40-year-old accepted a wildcard to play in this event, which seems likely to be her last ever appearance at SW19.
Winner: Emma Radacanu 40/1
Emma Radacanu’s results have been poor since winning the US Open.
But she is a player who thrives on the biggest stage, as shown by her incredible victory at Flushing Meadows.
The 19-year-old also reached the fourth round of Wimbledon last year in her maiden slam appearance.
A doubt heading into this year’s event because of injury, Radacanu might not be up to going all the way.
Her grand-slam pedigree, however, means she has as good a chance as anyone, especially with home support.