WalesThe Six NationsVS
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Wales head to Twickenham buoyed by their defeat of Scotland in Cardiff, but history is against the men in red, having not won at the home of English rugby since 2012.
England, as expected, bounced back from their defeat by Scotland in the opening round of matches by comprehensively defeating Italy in Rome and with the return of some big names from injury, coach Eddie Jones will be confident of victory.
However, Wales are likely also to see the return of Toby Faletau and will be hoping his experience can guide them to victory.
Having been overpowered in Dublin by Ireland on matchday one, Wales put in a much-improved performance to edge out Scotland 20-17 in Cardiff, and that result will give them hope as they head to Twickenham.
They have not won in London in a decade, but in recent visits, they have pushed England close, including in 2020, when England won 33-30, 2018 when England edged a low-scoring content 12-6, and 2016 when England won 25-21.
This is a transitional year for Wales under coach Wayne Pivac, though, and it would be a shock if they were to take the win at Twickenham, but the handicap market looks to offer some excellent betting value
Wales with a 14-point start is available with LeoVegas and with the best betting sites at Evens, and that looks a superb bet - England haven't covered a start of that size against Wales in the Six Nations at Twickenham since 2006.
The big news from the England camp heading into this weekend's match is the likely return of Manu Tuilagi and Courtney Lawes from injury.
Tuilagi is likely to return in the centre, and England fans will be relishing his partnership with Marcus Smith at 10, while Lawes is expected to replace Tom Curry in the back row.
Lawes will bring experience and physicality to the England pack in what's sure to be a tight battle up front.
Big things will also be expected of Smith on the back of a man-of-the-match performance against Italy and scoring all of England's points in their 20-17 defeat to Scotland.
Having been drafted into the British Lions squad last summer, Smith has progressed into one of the top talents in world rugby and his battle against opposite number Dan Biggar will be one to watch.
Many had written off Wales coming into this year's Six Nations, and they looked out of sorts in their opening-day defeat to Ireland in Dublin.
However, a revitalised Welsh side edged out Scotland in Cardiff, and they now head to Twickenham to take on fierce rivals England in good heart.
Wayne Pivac has added Toby Faletau to his squad, and he's likely to be pitched right into the starting lineup for this one.
Faletau's recall is a massive boost to Wales, who are currently without a host of top names, including Alun Wyn Jones, George North, and Justin Tipuric.
The number 8 won the last of his 86 international caps almost a year ago, however, he played 80 minutes for Bath against Leicester Tigers on Saturday and has declared himself raring to go against England.
Wales were impressive in defence against Scotland, and it's likely to be another tough afternoon at Twickenham, but the men in red can never be written off when facing England.
These two nations first clashed in 1881 and have faced each other 137 times - England have won 65 times, Wales 60 times, and 12 matches have ended in a draw.
Home advantage appears to play a huge part in this rivalry - England have won 41 of the matches at home while Wales have won 39 of their 66 home matches.
Last year's clash at the Millennium Stadium in Cardiff saw Wales run out 40-24 winners, en route to being crowned Six Nations champions.
Twickenham is the home of English rugby and is the largest dedicated rugby union venue globally, with a capacity of 82,000.
Opened in 1909, it was used as a venue for the Rugby World Cup in 1991, 1999, and 2015, hosting the final in 1991 and 2015.
And in 2016 and 2017, it hosted three NFL matches.
The current COVID-19 protocols in England mean that there are no set regulations, although fans are recommended to wear a mask and are encouraged to have proof of being double-vaccinated.
Matches between this pair are rarely dull, and Saturday's game looks set to be another tasty encounter as both sides look to build on their recent victories.
England were poor against Scotland, but with a packed Twickenham behind them, they should edge out a Welsh side that is still below full-strength.
Whether England can overcome a 14-point deficit is a different question, though, and Wales on the handicap looks a solid bet, with England likely to run out single-digit winners.