At the Olympic Stadium, West Ham and Chelsea play the "London derby", in the 32nd round of the Premier League.
The hosts desperately look for salvation points, while the guests, after the win against Leicester in the FA Cup, are aiming to enhance their great performance.
The Hammers made the surprise in November as they won the game against Chelsea (0-1), thanks to the goal scored by Cresswell, which arrived at the start of the second half.
Moyes' West Ham risks a dramatic relegation, even though the team started the campaign with other goals.
After the defeat on the field of Tottenham, now the Hammers, Aston Villa and Bournemouth are with equal points, but at the moment West Ham is in a higher position only because of their better goal difference.
Lampard's Chelsea, after the great win against Manchester City, confirmed their excellent form by the victory against Leicester and obtaining the FA Cup semi-final. The man who decided the challenge at the King Power Stadium was midfielder Barkley, finding the net magnificently.
15 games at home for West Ham this season (4W-3D-8L)
Only 23 goals scored by Hammers on their stadium
Last home victory against Southampton (3-1) was on 29.02
Chelsea scored 31 goals so far as a guest, which is an average 2 per game
.The Blues won in Birmingham against Aston Villa, before that they had 4 games in a row without a win as a guest.
When does West Ham vs Chelsea kick-off? Wednesday 20:15 UK
Where will West Ham vs Chelsea be played? London Olympic Stadium