Newcastle are the Premier League’s form team with 16 points amassed since the start of October.
Southampton have picked up just five points over that period, and could be 19th by the time this match kicks off.
A win here will move Newcastle up to third.
Eddie Howe is without suspended Joelinton, as well as long-term injury absentees Alexander Isak, Karl Darlow, Emil Krafth and Matt Ritchie.
Kyle Walker-Peters, Armel Bella-Kotchap and Tino Livramento are all still sidelined for the Saints, although Romeo Lavia is in line for a return.
Newcastle have taken seven points from their last three away matches, winning at Fulham and Tottenham and drawing at Old Trafford.
Southampton have the worst home record in the Premier League, but have beaten Chelsea and drawn with Arsenal at St Mary’s.
Heavy summer spending is yet to pay dividends for Saints. Just six teams have a worse expected goal difference, and Ralph Hasenhuttl seems to once again be on the brink of being dismissed.
Only Arsenal and Manchester City have a better expected goal difference than Newcastle. They are deserving favourites for this one.
Total Away Goals: Over 1.5
Newcastle have scored over 1.5 goals in four of their last six matches.
Their attack has generally been less effective on the road, but they scored twice away to Spurs and dispatched Fulham at Craven Cottage with a 4-1 victory.
Allan Saint-Maximin’s return to the starting line-up only enhances Eddie Howe’s team in possession.
Southampton’s defence has generally been solid this season, but there’s still value backing Newcastle to score two or more.
Anytime Goalscorer: Miguel Almiron
Nominated for Premier League Player of the Month, Miguel Almiron is one of the form players in European football right now.
With six goals in his last six games, the Paraguayan’s confidence is sky-high.
Many of those strikes have been spectacular in nature, and given this purple patch, he is great value to get on the scoresheet again at 5/1.
All odds are subject to change