Just three points separate the two clubs after Aston Villa drew with Manchester City and Southampton lost to Wolves last time out.
The postponement of last weekend’s matches has given Steven Gerrard and Ralph Hasenhuttl extra time to work with their squads ahead of this match.
Villa won this fixture 4-0 in 2021-22, but the Saints won on their three previous trips to Villa Park.
Winner: Aston Villa
Southampton are without Romeo Lavia and Tino Livramento and have lost nine of 10 away matches in the Premier League.
Villa have their own fitness concerns in Ollie Watkins and Emiliano Martinez, but they put in a much-improved performance against Manchester City last time out and look well set to build on that here.
With two wins, a draw and three defeats to their name in 2022-23, Southampton have been inconsistent as one would expect from a young team.
This is a trickier match than Villa’s points haul suggests – the hosts are worth backing at 11/10.
To Be Shown A Card: Douglas Luiz
Shown seven yellow cards in 31 starts last season, Douglas Luiz has been cautioned twice in just three starts in all competitions this term. An aggressive, and sometimes overly eager, ball winner, Luiz can get himself into trouble by diving into challenges.
The Brazilian is clearly vulnerable against a Southampton team which ranks third in dribbles per game. Players will look to take Luiz on, and a mistimed or clumsy challenge could see him land his third card of the campaign.
Most Corners: Southampton
Only four teams have conceded more corners than Aston Villa so far in 2022-23. Southampton average just 3.2 corners per match, but Villa are down at three.
Southampton edged the corner count in both matches last season, including their 4-0 defeat at Villa Park. This is a good price on the visitors to have the most corners on Friday night.
All odds are subject to change