Both teams are still in with a shot at qualifying for the finals heading into this match.
Portugal can secure a finals berth by avoiding defeat. Spain need a victory, setting up a potentially feisty Iberian Derby at Estadio Municipal.
The sides drew 1-1 when they met earlier this year and both have endured slip ups since then, with Spain winning just two of four and Portugal losing away to Switzerland.
Total Goals: Over 2.5
5/4 (Sporting Index)
There have been under 2.5 goals in three of five Nations League matches for each team, including their 1-1 in the summer. That contributes to a 5/4 price on the over, which seems like good value despite the low-scoring nature of the group thus far.
Spain need a win here, forcing them to chase the game from the first whistle.
Portugal are a threat on the counter, plus their attack is in fine form with 10 goals in four matches.
This could be an uncharacteristically open match with so much to play for – it’s worth backing the attacking talent on show to treat us to three or more goals.
To Be Shown A Card: Diogo Dalot
Expected to keep his place in the XI after a brace against the Czech Republic last time out, Diogo Dalot is a prime candidate to go into the referee’s notebook.
Dalot has three yellow cards in his last four Premier League starts, and could find himself outnumbered defensively with Spain’s Jose Gaya overlapping down the left.
Averaging 2.5 tackles and 1.5 fouls in the Premier League in 2022-23, this is a good price on Dalot to receive a card.
To Win Either Half: Portugal
Portugal won the second half when these teams last met, and with home advantage they will fancy their chances coming into this match. These are still two well-matches sides, however, which makes the 5/4 on Portugal to win the fixture unappealing.
The shorter odds on Portugal to win either half represent a better bet, particularly in the knowledge a draw is enough for them to progress.
All odds are subject to change