Mikel Arteta is expected to make significant changes to his Arsenal side here.
The Europa League will be viewed as an opportunity for squad players and youngsters, though Emile Smith Rowe is unavailable after suffering a muscle injury at Old Trafford.
Eddie Nketiah is likely to get the nod up front, while Matt Turner should replace Aaron Ramsdale between the sticks.
Zurich are appearing in UEFA competition for the first time since 2018-19 and won four consecutive matches in qualification.
Their preparation for the group stage opener hasn’t been ideal, however, as they come into this match off the back of consecutive defeats.
Match Result And Both Teams To Score: Arsenal
Arsenal have only kept one clean sheet in five matches and will likely rest some of their first-choice defenders for this fixture. Zurich have scored at least once in their last seven matches and have scored 12 times in six continental fixtures so far in 2022-23.
The Gunners conceded five times in six group stage matches in 2021-22, with both teams scoring in five of their eight knockout fixtures.
Anytime Goalscorer: Eddie Nketiah
Eddie Nketiah has shown flashes in limited minutes this year. He enjoyed a breakout of sorts in 2021-22, scoring five times in just eight league starts. A return of 0.54 goals per 90 might be inflated, but his small-sample expected goals numbers are every bit as impressive.
Facing a Zurich defence which has conceded six goals in two matches, Nketiah will fancy his chances of getting on the scoresheet. Some bettors will be tempted by 11/2 on the London-born striker to score at least twice.
To Score In Both Halves: Arsenal
Matching up with a porous Zurich back line, Arsenal will be able to create plenty of chances throughout.
Arteta will probably name a rotated attack, but the Gunners still have sufficient talent to cause the hosts problems. Teenager Marquinhos is in line for a first competitive start of the season and will be keen to prove himself.
Having scored in both halves in four of six league matches, this is a good price for Arsenal to do so again on Thursday night in a fixture they should win at a canter.
All odds are subject to change