Manchester United are heavily favoured, despite Omonia making them sweat in Cyprus last week.
An eventual 3-2 victory was entertaining for the neutral, but stressful for Erik ten Hag.
United now have six points from three Europa League matches, and can move to within touching distance of the last 16 with a victory.
Ten Hag saw his team battle to beat Everton at the weekend, while Omonia lost 1-0 to AEL on Monday night.
Half Time/Full Time: Manchester United/Manchester United
This should be a more straight-forward 90 minutes for the Red Devils, with Omonia Nicosia winning just one away match in UEFA competition in normal time since 2016-17.
Old Trafford will not be the most hostile atmosphere, but it will be intimidating for a team not accustomed to playing on such a stage.
Even with Anthony Martial injured again, Ten Hag will name a strong team, which should be able to take control of this match early on.
Anytime Goalscorer: Marcus Rashford
It’s unclear if ten Hag will start Marcus Rashford here, but even if reduced to a cameo role, the England international is a threat.
Rashford scored two and assisted one in Cyprus last week, and could torment the Omonia defence again at Old Trafford.
With United able to move onto nine points with a win, Ten Hag could name Rashford in his XI here in the hope that he can rest him on matchday five and six.
Either way, Omonia’s defenders will not be keen to see Rashford after his performance last week.
Both Teams To Score: Yes
United have kept just one clean sheet at home in six matches in all competitions this season.
Omonia have failed to score just once in five Europa League matches this term.
The away side proved they can trouble this United defence last week. This market is asking if Omonia can score even once, and you have to like their chances, even if Ten Hag names a first-choice defence.
All odds are subject to change