Spurs and Frankfurt are on four points each coming into matchday three, pursuing Sporting with six points and looking to stay ahead of Marseille on three.
Group D is beautifully poised for the second half of the group stage, and a victory for either team in north London would be a massive step towards a last 16 spot.
Having put in a battling performance to beat Brighton at the weekend, Spurs will be happy to return home for this fixture. Frankfurt, on the other hand, need to bounce back after a surprise 3-0 loss to Bochum.
To Win To Nil: Tottenham
While it is just two wins in five matches overall for Antonio Conte’s team, they have been a force at home. They have won all five of their fixtures at Tottenham Hotspur Stadium, and kept a couple of clean sheets in the process.
Spurs had the better chances when they faced Frankfurt last week, and the away side had their confidence take a considerable hit due to the draw with Bochum.
To Be Shown A Card: Pierre-Emile Højbjerg
Industrious and unafraid of a tackle, Pierre-Emile Højbjerg has been shown two yellow cards in the Champions League already. The stricter officiating in continental competition can work against players like Højbjerg, and he is a definite booking candidate again on Wednesday night.
Højbjerg commits to challenges, averaging 1.7 fouls per match in the Champions League. While the hosts will want to stick to their counter-attacking principles, there are times when he could be left isolated in midfield if they commit men forward.
This is a good price.
First Goalscorer: Heung-min Son
Harry Kane is a doubt for this match with an ankle knock. Kane will probably still start, but could be slightly less mobile. That could see Kane further embrace the role of playmaker, setting up chances for Heung-min Son.
The former Bayer Leverkusen forward scored a scintillating hat-trick against Leicester, but hasn’t been at his best from a goal-scoring perspective.
Son is getting chances, though, and he could be the difference-maker here.
All odds are subject to change