Milan continue to deal with an almighty injury crisis, with Alexis Saelemaekers, Simon Kjaer, Davide Calabria, Zlatan Ibrahimovic, Alessandro Florenzi and Mike Maignan all out.
Theo Hernandez returns for this fixture, though, and the Rossoneri got a great result at the weekend, beating Juventus 2-0.
Chelsea made light work of their weekend meeting with Wolves, notching a 3-0 win to make it three consecutive victories and four matches unbeaten under Graham Potter.
Level on four points apiece, victory for either side here would put them in a strong position in Group E with just Salzburg and Dinamo Zagreb to play.
To Win Either Half: Chelsea
Chelsea have won their last three, which might tempt some to go for the Blues to take all three points on Tuesday night.
Milan have been superb at home, however, winning five of six at San Siro, including the triumph over Juventus at the weekend. Their only defeat came against an impressive Napoli side.
While away form is an issue for Chelsea, performances have been good under Potter, and you can feel confident that they will win at least one half.
Both Teams To Score: Yes
The fixture at Stamford Bridge was the first time Milan have failed to score since August. Even with significant absentees, their forward line was in full flow at the weekend, with 21 shots against Juventus.
Rafael Leao was a threat throughout last Wednesday, and Brahim Diaz is likely to find space between the lines.
There were plenty of chances for both teams last week – both teams to score is a value option for this one.
Anytime Goalscorer: Rafael Leao
The duel between Leao and Reece James is one of the key factors for this match. Leao is box office, and was unafraid to attack the England international in west London.
He already has four goals and four assists in eight Serie A starts, and got off six shots against Juventus at the weekend.
All odds are subject to change